General information on Amyloidosis
Amyloidosis is a rare condition in which the dog’s ability to metabolize the amyloid protein is affected. In dogs with amyloidosis, the amyloid protein is primarily deposited in the kidneys. Once the protein is in the kidneys, it inhibits the kidneys from functioning normally. The kidneys then, in turn, expel excessive amounts of protein in to the urine which leads to chronic kidney failure. In amyloidosis, other organs, such as the spleen or liver, can also be subject to the amyloid protein deposits. Should this occur, the affected organ will also malfunction leading to chronic failure as well. There are several causes of amyloidosis. Amyloidosis can be caused by inflammatory conditions and infections. The primary cause of amyloidosis, however, is heredity. Any breed can be affected by amyloidosis and the average age for an affected dog to present symptoms of amyloidosis is nine, but some breeds are prone to present symptoms as young as five.
Symptoms of Amyloidosis
Some of the symptoms of amyloidosis may be fever, excessive urination, swollen joints, excessive thirst, loss of appetite, weight loss, vomiting, inflammation, ascites, edema, difficulty breathing, and blood clots. The symptoms of amyloidosis may present in a cycles.
Treatments for Amyloidosis
The treatment for amyloidosis is to first identify the cause. Should the amyloidosis be caused by an underlying condition, then the treatment for the amyloidosis is to treat the underlying cause. Additional treatments for amyloidosis include treatments for chronic kidney failure and medications, such as Colchicine, that help to reduce inflammation that is caused by uric acid.
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